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Aroda VR, Edelstein SL, Goldberg RB, Knowler WC, Marcovina SM, Orchard TJ, Bray GA, Schade DS, Temprosa MG, White NH, Crandall JP

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Verdict at a Glance Amycretin shows potentially superior weight loss (up to 24.3% in Phase 1b/2a) compared to semaglutide (14.9% in STEP 1), driven by its dual GLP-1/amylin mechanism in a single molecule

The pool of circulating DPP-4 in animals fed RC reflects contributions from endothelial and bone marrow cells and osteoclasts but not from enterocytes, hepatocytes, cells from the whole kidney, or adipocytes

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