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A rare case involved a woman who had immediate adverse reactions to both cyanocobalamin and hydroxocobalamin, by both injection and oral delivery

In contrast, rats supplemented with the active form of vitamin D, 1,25(OH)D, showed restored LTP responses following tetanic stimulation, suggesting that vitamin D supports synaptic plasticity by preserving postsynaptic responsiveness under neurotoxic conditions (78)

Their bodies naturally slow down with age, and they might have other health issues

secondly, relative to other organs, the brain has lower levels of ROS scavenging enzymes and thirdly the brain is 60% fat a high proportion of which is unsaturated fatty acids that are highly susceptible to lipid peroxidation

American Journal of Physiology-Lung Cellular and Molecular Physiology 287

Regular Lipo B12 shots can help strengthen your bodys natural defense mechanisms