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51,52 Hemodialysis can cause increased production of hepatocyte growth factor (HGF)

Unlike conventional cellular and mammalian models, zebrafish offer distinct advantages for real-time live imaging, rapid genetic manipulation, and conserved immune and metabolic pathwaysmaking them particularly suitable for mechanistic studies of natural products and novel compound screening (Sukardi et al., 2011)

Vitamin C and Vitamin E are two of the most important partners for glutathione

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Utilizing a biomimetic lipid bilayer (liposomal delivery) allows these nutrients to bypass digestive degradation and move directly into the bloodstream, ensuring the molecular precision required for elite performance is actually achieved

Given the recent clinical trial data that suggests neurotoxicity issues with IACS 51 , we moved forward with 5FU and metformin for in vivo evaluation