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Its been a hot topic in my practice, so it was good to read this article, and it kind of reinforced what Ive been saying, which is we dont know

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This results in: Reduced appetite and caloric intake Enhanced satiety between meals Elevated metabolic tone and mental energy Tesofensine acts centrally to suppress appetite by increasing monoaminergic neurotransmitter levels in the hypothalamus. Astrup, The Lancet What makes Tesofensine unique isnt just its effect on hunger it also elevates dopamine , which may improve mood, motivation, and drive during a cut

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While they can remove body fat from specific areas, they wont stop you from gaining weight elsewhere