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J Hepatol (2019) 70:53144
GIP supplementation was also shown to be ineffective in the 1990s when intravenous (IV) GIP was introduced to hyperglycemic patients with no effect on their blood glucose though physiologic rather than pharmacologic concentrations were supplied [20]
Vollmer K, Holst JJ, Baller B, et al
10.2337/db18-1465-P Diabetes
Its possible some of those holdouts were waiting for a more convenient option, without the hassle of a needle and Lilly is betting their new pill will make GLP-1s accessible for many of them
However, if evidence for hard endpoints (e.g., live birth) is insufficient and costs or washout constraints are significant, the net utility may approach zero or remain uncertain
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