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In addition to the physical protection provided by the skull, the brain is protected by a special biological barrier, including the BBB, blood-cerebrospinal fluid barrier (BCSFB), and cerebrospinal fluid-brain barrier (CSF-brain barrier) (Figure 1), among which the BBB has the lowest permeability

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albicans achieves stable commensal colonization on healthy oral, esophageal, vulvovaginal and other mucosal epithelial surfaces by regulating the expression of adhesins and virulence factors, adapting to the nutrient-poor microenvironment of mucosae, and evading host immune surveillance with the synergistic effect of the resident microbiota that competes for nutrients and restricts its overgrowth (Schille et al., 2025)