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The pharmaceutical company Amylin Pharmaceuticals licensed the compound and spent years developing it into a drug suitable for human use
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But why
The neuroprogressive nature of major depressive disorder: pathways to disease evolution and resistance, and therapeutic implications
The shift to first-line in just a few years is significant and I believe approvals like Foundayo (orforglipron) will add to that shift
Specific to GLP-1, berberine increases intestinal GLP-1 secretion through multiple pathways
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