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The Ecuadorian Laron and Brazilian Itabaianinha cohorts with congenital mutations in the GH and GHRH receptors, respectively, both provide a unique and arguably the purest examples to evaluate the effects of chronic severe IGF-I and both severe GH and IGF-I deficiency, respectively, with severe hypoinsulinemia being the common denominator in both cohorts (151, 152) ( Table 1

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163 CBP/p300 family Two paralogous acetyl transferases that have been widely recognized to function as transcriptional co-activators to enhance transcriptional activation are CREB binding protein (CBP) and p300