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However, the pesticide DDT and its main metabolite DDE (both at 10 M) negatively impacted AR-regulated expression of PSA and other AR target genes (prostate-specific membrane antigen, PMSA , and Insulin-like Growth Factor-1, IGF1 ) in human LNCaP and VCaP PCa cells, blocking the recruitment of AR to the PSA promoter region [283]

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