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The inhibition of H3R via H3R antagonists enhances histamine release, thereby suppressing the neuroinflammatory effects of microglia and preventing dopaminergic neuronal degeneration [58,61]

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Administering these vitamins via injection bypasses gastrointestinal absorption barriersuseful for patients with pernicious anemia, post-gastrectomy states, chronic metformin or acid-suppressing therapy that impairs B12 absorption, or conditions that reduce intestinal uptake

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