Association of glucagon-like peptide-1 receptor agonist vs dipeptidyl peptidase-4 inhibitor use with mortality among patients with type 2 diabetes and advanced chronic kidney disease
In July 2024, the FDA issued an alert that warned of the risks of dosing errors in compounded semaglutide products after receiving reports of patients self-administering GLP-1s at dosages five to 20 times higher than prescribed
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Those numbers appear clear until we consider individual differences, adherence challenges, and the differences between controlled trial settings and real-world use
This allows compounding pharmacies to get in the game
Based on published phase 2 clinical trial data, the most commonly reported adverse effects include: Gastrointestinal effects: Nausea, vomiting, diarrhoea, constipation, and reduced appetite are the most frequently reported side effects