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The GLP1R rs6923761 variant and GIPR rs1800437 variant are associated with differences in receptor sensitivity and signaling strength

This more consistent elevation in plasma GLP1 levels, and therefore potential for an uninterrupted receptor activation profile, appears to result in greater improvements in HbA1c levels when compared with shortacting GLP1 compounds (Buse et al., 2009)

it also contains a compound that mimics a second gut hormone, GIP (glucose-dependent insulinotropic polypeptide)

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Direct transfer of alpha-synuclein from neuron to astroglia causes inflammatory responses in synucleinopathies

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