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Proteins 75 , 187205 (2009)

However, like any treatment, they come with considerations that are carefully managed in a clinical setting: Allergic Reactions: While rare, there is always a possibility of an allergic reaction to any substance introduced into the body

Altered gastric motility from semaglutide could also change tramadol absorption unpredictably, potentially reducing pain relief effectiveness or increasing opioid-related side effects

Frontiers in Aging Neuroscience 2016

These peptides are present in various biological processes and can have significant effects on the health and functioning of the human body, including the oral cavity [32]

That doesnt mean its toxic