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Clinical trials show that on average, people achieved a weight reduction of over 10% of their initial body weight in over one year

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All GLP-1 receptor agonists and tirzepatide carry a boxed warning about thyroid C-cell tumors seen in rodent studies and are contraindicated in patients with a personal or family history of medullary thyroid carcinoma (MTC) or Multiple Endocrine Neoplasia syndrome type 2 (MEN2)

Izumi M, McDonald MC, Sharpe MA, Chatteriee PK, Thiemermann C

The constant internal noise faded, and everyday conversations became clearer again

Kabra UD, Jastroch M (2023) Mitochondrial dynamics and insulin secretion