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(41) discovered that the gene expression of IL-10 was upregulated to the maximum in human leukocytes between 4 and 6 hours after endotoxin infusion, indicating the onset of a transition from a pro-inflammatory to an anti-inflammatory response in this period

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Conversely, the absence of mechanical stimuli suppresses integrin expression and activation which in turn blunts IGF-1 signaling, thereby limiting the anabolic effects of IGF-1 in the skeleton

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