Yang B, Gelfanov VM, El K, Chen A, Rohlfs R, DuBois B, et al
How PlexusDx Supports a More Personalized Approach PlexusDx's Precision Peptide Genetic Test may help provide context about your individual predispositions in key GLP-1 pathwaysincluding GIPR rs1800437, GLP1R rs6923761, FTO rs9939609, and MC4R rs17782313 variants
Annual Costs (2025) Retail Pharmaceutical (Wegovy/Mounjaro as proxies): Without insurance: $12,000-16,800/year With insurance coverage: $1,200-3,600/year (copays) Retatrutide will likely price similarly when approved Research Peptide Suppliers: Maintenance dose (4mg weekly): $3,600-6,000/year Higher dose (8mg weekly): $7,200-12,000/year Requires self-sourcing from suppliers like Red Fox Peptides (third-party HPLC/MS testing, 98%+ purity verification, with delivery within 2-4 days for Canadian customers) Dose Reduction Strategies Many patients successfully maintain on lower doses than required for active weight loss: Lost weight on 12mg weekly
At the maintenance dose of 10 mg per week, one vial lasts exactly one week
Insulin requires extreme caution with Retatrutide
Dosage and administration Semaglutide is typically injected once weekly, with a gradual dose escalation to reduce side effects
