Spanagel R, Herz A, Shippenberg TS
Lipoprotein Metabolism during Acute Inhibition of Hepatic Triglyceride Lipase in the Cynomolgus Monkey
And that comes essentially from the efficiency of trying to intervene in targets that underlie multiple different pathologies, all of which have big markets
10.1371/journal.pone.0120270 491 YadavS
Aliment Pharmacol Ther 35(5):516528 van Wijck K, Lenaerts K, Grootjans J, Wijnands KA, Poeze M, van Loon LJ et al (2012) Physiology and pathophysiology of splanchnic hypoperfusion and intestinal injury during exercise: strategies for evaluation and prevention
This study reports that adenosine-dependent Per2 stabilization facilitates HIF-elicited cardiac metabolic adaptation and ischaemia tolerance