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Regarding A metabolism, several miRNAs including miR-9, miR-29, miR-135, and miR-186 are significant regulators of Beta-Secretase 1 ( BACE1) enzyme levels which is central in A generation (Wang et al., 2019)

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Because the pituitary remains largely unaffected and is able to maintain intracellular T3 levels while the rest of the body suffers from significantly reduced intracellular T3 levels, there is no elevation in thyroid-stimulating hormone (TSH) despite the presence of wide-spread tissue hypothyroidism, making the TSH and other standard blood tests a poor marker to determine the presence or absence of hypothyroidism

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