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However, GLP-1 also exhibits pleiotropic effects such as reducing appetite, enhancing neuroprotection, and modulating immune cell responses
Its recommended to seek medical advice if experiencing the following or if these issues persist or worsen: swelling sensation in the body redness and pain at the injection site temporary itching of the skin mild diarrhea There may also be a risk of: congestive heart failure anaphylaxis polycythemia vera, which is a type of blood cancer peripheral vascular thrombosis, which involves blood clots pulmonary edema If experiencing difficulty breathing, swelling, and hives, patients must seek emergency medical help
semaglutide 1 mg (Ozempic, Novo Nordisk) plus placebo
Conservative guidelines recommend 28 days
24 The treated subjects had similar age and HbA1c of that reported in Italy, although had a shorter duration of diabetes but with a higher cardiovascular burden (around 30% had established cardiovascular disease)