10.1038/cdd.2016.119 10 BrookesP
Current Microbiology, 75 (3), 266271
Store lyophilised GSH at -20 C, sealed and protected from light and moisture - the cysteine thiol is highly susceptible to oxidation
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Several findings demonstrate its therapeutic role against neurodevelopmental disorders, including Angelman syndrome, Fragile X syndrome, sleep-wake disorders, neural tube defects and attention-deficit hyperactivity disorder
Glutathione peroxidase 4 senses and translates oxidative stress into 12/15-lipoxygenase dependent- and AIF-mediated cell death