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Data availability All data are available in the main manuscript and supplementary material and all relevant data is available from the authors

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At 1 year, 90% of all treated patients remained off long-term prophylaxis, with 8 patients who were treated with 50 mg attack-free

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Nicole Avena completed her PhD in Neuroscience and Psychology from Princeton University, followed by a postdoctoral training fellowship at The Rockefeller University in New York City

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