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Acta Pharmacol Sin Tian X, Gao Z, Yin D et al (2023) 17beta-estradiol alleviates contusion-induced skeletal muscle injury by decreasing oxidative stress via SIRT1/PGC-1/Nrf2 pathway

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doi: 10.1158/0008-5472.CAN-03-3845

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The European Medicines Agency granted centralized approval in July 2011, but marketing authorization was withdrawn at the request of the sponsor in 2014 for commercial reasons (not safety)