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Description

In brown and beige adipose tissue, glucagon signaling increases uncoupling protein 1 (UCP1) expression and thermogenesis, directly raising resting energy expenditure

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GIP receptors exist in fat tissue, the brain, and the pancreas

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In both studies, people taking the drug lost about 20% of their body weight over a year.

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Some patients experience rapid weight regain when stopping GLP-1s, which could affect surgical planning if significant weight change occurs

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Emerging Frontiers in GLP-1 Therapeutics: A Comprehensive Evidence Base (2025)

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