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To explain this phenomenon, many hypotheses have been proposed, includingthe reduced efficiency of peripheral deionisation of exogenous T4 compared to endogenous thyroidal secretion (12)

doi:10.1111/j.1398-9995.2009.02325.x Gray SL, Anderson ML, Dublin S, et al

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Androgen metabolism via 17-hydroxysteroid dehydrogenase type 3 in mammalian and non-mammalian vertebrates: comparison of the human and the zebrafish enzyme

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