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Pharmacologic and genetic suppression of GPX4 induces ferroptosis, DNA damage, and decreased cell viability in vitro via a novel mechanism of mTOR signaling pathway inhibition

Journal reference: Ceasovschih A, Asaftei A, Lupo MG, et al

The random-effects model was used to calculate the relative risk (RR), mean difference (MD), and 95% confidence intervals (95%CI)

Treatments are customized , and weekly or monthly doses may be recommended based on individual needs

Furthermore, ferroptosis of granulosa cells in PCOS has different effects on ovarian function, which may be related to the severity of PCOS and individual heterogeneity

CPT1 facilitates transfer of the acyl group from CoA to carnitine, thereby enabling transport of the acyl-carnitine through the outer mitochondrial membrane towards the mitochondrial matrix