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Furthermore, liraglutide inhibits the expression levels of TNF--mediated NF-B activation in podocytes (Ye et al., 2019)

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A persistent criticism of this mechanism has been the high extracellular concentrations (mmol/l) required to observe rapid effects, although lower concentrations of metformin (50100 mol/l) do inhibit Complex I in rat hepatoma (H4IIE) cells after several hours