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All published evidence is from animal or in vitro studiesno peer-reviewed human clinical trials have been completed as of 2026

The half-life of UA and UA-glucuronide ranges from 17 ~ 22 h, whereas the half-life of UA-sulfate is slightly longer, varying between 25 ~ 58 h (7)

doi: 10.1016/j.jare.2024.01.019 Summary Keywords hepatoprotective effect, glutathione, Ganoderma lucidum extract, vitamin C, gut microbiota, metabolomics Citation Wang Y, Zhang Y, He Y, Zhang S, Huang B, Wang Y, Lin W, Xiao W, Zou Z and Cui G (2025) GGV formula attenuates CCl 4 -induced hepatic injury in mice by modulating the gut microbiota and metabolites

Therefore, therapies attempting to depress ACE2 should not impact the ACE1/ACE2 ratio 11

Adler BL, Yarchoan M, Hwang HM, et al