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10.1038/s41416-021-01366-1 43 TongG.PengT.ChenY.ShaL.DaiH.XiangY.et al (2022)

It regulates blood sugar by serving as a glucose disposal site

De Araujo is finding that adverse reactions might be caused by how the drug differs from the naturally occurring peptide hormone: The hormone acts mostly locally and degrades quickly, while the medicine works mainly on the brain and is designed to stick around in the body

Enhanced metabolic health has broader implications, potentially improving overall wellbeing

Energy throughput goes up, but ATP availability relative to demand goes down

But when you swallow the drug, stomach enzymes dissolve some before your gut's mucosal lining can absorb and pass it to your bloodstream