In each rat, two sterile sponges (1 cm x 1 cm x 0.25 cm (V=0.25 ml)) with the same quantities of NaBPC157, (solution50 g, 10 g, 10 ng/ml) or the reference agents, cimetidine (10 mg, 100 mg, 500 mg/ml), ranitidine (2.5 mg, 25 mg, 250 mg/ml), famotidine (10 mg, 50 mg, 100 mg/ml) and sucralfate (1 mg, 5 mg, 10 mg/ml) were implanted subcutaneously in the lumbar region
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It also directly binds to KDM6A, leading to the demethylation of H3K27me3, the upregulation of Bcl-2, the suppression of Foxp3 expression, and ultimately the promotion of iTreg apoptosis [83]
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