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doi:10.1016/j.nut.2020.111024

When this barrier is compromised by nonsteroidal agents like ibuprofen (which block the good prostaglandins that make mucous), it can create ulceration and decrease peptide secretion from the gut

Most patients experience mild gastrointestinal adjustmentnausea, constipation, or reduced appetite for favorite foodsthat typically resolves within 1-2 weeks