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Mauvais-Jarvis F, Manson JE, Stevenson JC, Fonseca VA

Improvements in visceral adiposity exceeded those observed in the comparator group receiving a sodium-glucose cotransporter 2 (SGLT2) inhibitor

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Underdosing means the medication works slower or not at all

used gold standard hyperinsulinemic euglycemic and hyperglycemic clamp methods in 117 patients with T2D to confirm a significant improvement in the clamp disposition index, a measure reflecting both increased insulin secretion and sensitivity, in tirzepatide 15 mg vs

Insulin sensitivity and metabolic markers All three medications improve insulin sensitivity, but the magnitude varies