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This phenotype is consistent with the concept that smaller cells are primarily engaged in proliferation, whereas larger cells often shift to alternative metabolic activities, diverting energy from replication to other cellular processes (Vander Heiden et al., 2009)

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Luminescent signal measured in each well was expressed as % of signal elicited by 50 nM dostarlimab in the same plate and the mean of results obtained in 3 independent plates was calculated

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