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However, the potential for delaying or preventing the progression of T2DM in patients treated with GIP and GLP-1 remains uncertain, as there is currently no definitive evidence from human studies demonstrating that enhanced incretin activity directly affects -cell mass or alters the progressive loss of insulin secretory capacity in humans

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Nausea, vomiting, diarrhea, and constipation are frequently reported, especially during initial dose escalation phases

Lu et al., 2021)

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The tissue-specific activities are regulated by the interaction of many signalling pathways, notably the cAMP/PKA and PI3K/Akt pathways, which together mediate GLP-1's metabolic and protective effects