The anti-endometriosis effects involve plentiful molecular mechanisms and targets, including anti-proliferative (CCNE1, CDK2, and CDK4), anti-inflammatory (PGE2, COX-2, TNF-, NO, IL-1, IL-6, and IL-8), anti-angiogenic (VEGF, matrix metalloproteinase and Ang-1), pro-apoptotic (Bax, Bak, Bcl-2, Bcl-xL), autophagy (Beclin 1, LC3-II/LC3-I), endoplasmic reticulum stress, endoplasmic reticulum apoptotic pathway, mitochondrial apoptotic pathway and caspase cascade, anti-migratory invasion (MMP-2, MMP-9, TIMP1, E-cadherin, N-cadherin, Snail and Slug), regulation of estrogen and progesterone receptors, and anti-fibrotic (E-calmodulin, -SMA, type I collagen, wave proteins and fibronectin)
No adverse effect on fertility was observed at 50 mg/kg/day (systemic exposures up to 10 times the human exposure at 40 mg/day based on AUC)
Recent studies have found that TCM may have great potential in regulating mitochondrial dysfunction in the treatment of DN
Amperage16A
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Avoid temperature above 60C
