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Those at greatest risk of vitamin B12 deficiency are vegans and vegetarians, who get little to no B12 from the diet

They are listed here as a reference for researchers investigating Dihexa

While it might not look so strange at first glance, when you build a model you see that the nitrogen lone pair is pointing out at a weird angle that prevents overlap with the adjacent carbonyl

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Each single-compound approach has a different dosing logic than the combination, and the comparison clarifies why the combination dosing is designed the way it is