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However, these cases are very uncommon , and just because someone taking semaglutide develops jaundice does not always mean the drug caused it

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Recent studies have further revealed that ACSL4 is highly expressed in the fibroblasts of the IBD gut, actively secreting phospholipids rich in PUFAs, which, upon uptake by epithelial cells, lower the threshold for ferroptosis, thus forming a cross-cellular ROS network between fibroblasts, epithelial cells, myeloid cells, and endothelial cells [146]

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