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A trial of 40 cognitively normal amyloid-positive individuals will explore the feasibility of using an intranasal insulin delivery device (NCT05006599)

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Y = B max *X/(Kd + X) + NS*X + Background (X: ligand concentration, Y: total binding, B max : Maximum binding, Kd: Equilibrium dissociation constant, NS: slope of the nonlinear regression, Background: measured binding with no added ligand)

By randomizing the order of the interventions (L-carnitine and placebo) and ensuring a 1-week washout period between each treatment, the study controls for potential carryover effects

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Fundam Appl Toxicol 7, 54765