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The combination is particularly useful because bupropion is one of the few antidepressants associated with weight loss rather than weight gain, and the effects can be modestly additive when combined with a GLP-1

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In the first phase of the current study, SR18, docked to GLP-1R, was subjected to 1 s MD simulations to directly compare its agonist-like properties with the established agonists and antagonists of GLP-1R reported earlier