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Palumboism (rare and long-term) Long-term abuse of GH or secretagogues like MK-677 could theoretically contribute to visceral organ growth and distended abdomen, known as Palumboism

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The delicate balance of estrogen and testosterone that exists pre-menopause tends to keep body fat in the lower body, away from the belly, so the midlife estrogen dip can leave women perplexed and upset when their pants no longer buttoneven if theyre still eating well and exercising