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In a previous study, the same group did not observe Ca 2+ response effects induced by exposure to chemotherapeutic agents in cultured mouse DRG and Chinese hamster ovary (CHO) cell line (Nassini et al., 2011), although chemotherapeutic agent evoked an antioxidant GSH-sensitive Ca 2+ response in the CHO cell line and DRG neuron

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instead, it provides a natural, rhythmic stimulus