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The knockout of MMR genes ( MSH3 , PMS1 , MSH2 and MLH1 ) ameliorates both early-onset phenotypes in MSNs and late-onset manifestations in cortical neurons, including somatic CAG-repeat expansion, transcriptionopathy and mHTT aggregation (Moss et al., 2017)

2.6 Chromatographic analysis of TMA-related compounds TMA and TMAO were measured through LC-MS/MS analysis using a system composed by an UHPLC Ultimate 3000 (Thermo Fisher Scientific) and a Q-Exactive Plus high-resolution mass spectrometer (Thermo Fisher Scientific)

Protein-Protein Interaction (PPI) network The DEPs were imported into the STRING database ( for protein interaction network analysis and subcellular localization analysis

Wegovy and Zepbound carry FDA approval for chronic weight management

Shock 42(2):129132