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doi: 10.3389/fonc.2026.1680441 Received 06 August 2025 Revised 20 January 2026 Accepted 20 January 2026 Published 03 February 2026 Volume 16 - 2026 Edited by Arumugam Jayakumar, University of Texas MD Anderson Cancer Center, United States Reviewed by Enrico Martin, University Medical Center Utrecht, Netherlands Fei Song, Affiliated Hospital of Nantong University, China Updates Copyright 2026 Zhu, Shen, Yang, Han, Li, Xie, Tan, Lu, Ji and Zhang

65 , S630S631 (2013)

Furthermore, human glioblastoma cells do not rely much on circulating glutamine for proliferation but rather more on glutamate to synthesize glutamine via glutamine synthetase to fuel purine biosynthesis 193

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