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Third, FBFs prevent premature meiotic entry of SPCs by inhibiting expression of target mRNAs that encode differentiation-promoting regulators, such as GLD-1 (Millonigg et al., 2014), and GLD-3 (Eckmann et al., 2004), as well as structural components of meiotic chromosomes, such as HTP-1,-2 orthologs of human HORMAD1 and 2 (Merritt and Seydoux, 2010)