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Chronic hypoxia induces a vicious cycle of decreased PP2A activity and increased p--syn We have found that hypoxia promoted -syn phosphorylation, but the molecular mechanism remained unclear

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This review aims at providing a broad view of PAIS, ranging from the molecular/cellular level to the whole organism, to provide a theoretical background and to introduce notions that could help understanding how PAIS can have both clear core features and a large set of diverse symptoms