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Although the hypotensive effect of GLP-1 RAs seems to be manifested by BW losing, other mechanisms not related to BW might be implied by the mediation meta-analysis, which suggests an existence of BW-independent hypotensive effect of GLP-1 RA, along with the clinical evidence of weak or no correlations, and difference in time course between BP lowering and BW reducing effects

This research did not receive any specific Grant from funding agencies

Authoritative scientific references: National Center for Biotechnology Information (NCBI) U.S

Frequent vomiting, persistent nausea, or inability to maintain normal food intake should always be evaluated

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Obesity and Weight Studies: Published Phase 2 data (NEJM, 2023) showed up to 24.2% mean body weight reduction at 48 weeks