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Peer review Peer review information Nature Reviews Endocrinology thanks Michael Pollak and the other, anonymous, reviewer(s) for their contribution to the peer review of this work

The biological rationale is interesting but unproven

Some researchers also investigate combination approaches, pairing GLP-1 agonists with other peptides that target complementary pathways

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Activation here produces two effects: increased sexual arousal (via the oxytocin pathway) and reduced appetite