Here is what each group received: 1mg group: 1mg weekly for the full 48 weeks, no escalation 4mg (starting at 2mg): Started at 2mg, escalated to 4mg after 4 weeks 4mg (starting at 4mg): Started directly at 4mg, no escalation 8mg (starting at 2mg): Started at 2mg, escalated through 4mg to reach 8mg 8mg (starting at 4mg): Started at 4mg, escalated to 8mg after 4 weeks 12mg (starting at 2mg): Started at 2mg, escalated through 4mg, 8mg to reach 12mg The weight loss results at 48 weeks told a clear story
The change in pace is completely normal and doesnt mean your plan has stopped working
Even if you have a high-dose pen that could last for four months of microdoses, you cannot safely use it that long
Symptoms usually decrease over time as the body adjusts
Davenport)
Exenatide and lixisenatide are primarily cleared through the kidneys, while liraglutide, dulaglutide, semaglutide, and tirzepatide undergo proteolytic degradation throughout the body with minimal renal excretion of intact drug
