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Although data from early phase trials suggest that retatrutide is well tolerated with a similar adverse event profile to GLP-1 RAs, additional research assessing long-term safety and efficacy of retatrutide in people living with obesity and/or T2D (including cardiovascular outcomes) is awaited over the next five years

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They are not associated with any increase in the risk of uterine cancer

Rapamycin was administered to dogs at a dose of approximately 0.025 mg/kg, using 0.25 mg increments