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Heritability measurements have been derived from investigations on identical twins, fraternal twins and sibling concordance, including a survey of more than 2 million Swedish households in 2014, 71 which is the largest human-based ASD study to date, eventually estimating the heritability of ASD as ranging from 52% to 90%

Currently, GPx3 is considered a new tumor-suppressor gene [23], and its hypermethylation, which is associated with the further down-regulation of GPx3, was observed in patients with Barretts esophagus [54], endometrial adenocarcinoma [55] and prostate cancer [56]

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