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Enhanced lactate production resulting from upregulated glycolysis further induces endometrial H3K18 lactylation and regulates redox homeostasis and apoptotic balance, thereby facilitating endometrial remodeling to ensure successful implantation (49)

GLP-1 drugs contain peptide molecules that cannot pass the skin barrier through the current transdermal patch technology

Replacement of proteins by the artificial small-sized dimeric macrocycles seems to have advantages for drug development, such as production by chemical synthesis and amenability to chemical modifications for the control of pharmacokinetics, protease resistance and drug delivery, and such controlled properties should be carefully evaluated in future research and development

Clinical values of serum NGAL combined with NT-proBNP in the early prognosis of type 1 cardiorenal syndrome

Semaglutide and tirzepatide are the two most widely discussed active ingredients in this category, and they've become recognized for their role in weight management after clinical trials demonstrated significant weight loss outcomes in study populations

NDA 19-998/S-013